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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HCN4 All Species: 12.12
Human Site: S522 Identified Species: 44.44
UniProt: Q9Y3Q4 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9Y3Q4 NP_005468.1 1203 129042 S522 A L I Q S L D S S R R Q Y Q E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001115891 777 86237 E122 V G I T F F K E E N S P P W I
Dog Lupus familis XP_535535 746 84568 Q91 L N H A D F M Q R Q F G A M L
Cat Felis silvestris
Mouse Mus musculus O70507 1186 127396 S522 A L I Q S L D S S R R Q Y Q E
Rat Rattus norvegicus Q9JKA7 1198 128742 S522 A L I Q S L D S S R R Q Y Q E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_425050 1188 129247 S496 A V L Q S S Q S R Q F R A Q E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_686078 1078 119210 G423 K M V N D T W G Q Q Y S Y A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 48.8 57.9 N.A. 93.6 95.5 N.A. N.A. 70.4 N.A. 61 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 N.A. 56.1 59.6 N.A. 94.9 96.3 N.A. N.A. 77.5 N.A. 68.5 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 N.A. 6.6 0 N.A. 100 100 N.A. N.A. 40 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 6.6 6.6 N.A. 100 100 N.A. N.A. 66.6 N.A. 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 58 0 0 15 0 0 0 0 0 0 0 0 29 15 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 29 0 43 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 15 15 0 0 0 0 0 58 % E
% Phe: 0 0 0 0 15 29 0 0 0 0 29 0 0 0 0 % F
% Gly: 0 15 0 0 0 0 0 15 0 0 0 15 0 0 0 % G
% His: 0 0 15 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 58 0 0 0 0 0 0 0 0 0 0 0 15 % I
% Lys: 15 0 0 0 0 0 15 0 0 0 0 0 0 0 0 % K
% Leu: 15 43 15 0 0 43 0 0 0 0 0 0 0 0 29 % L
% Met: 0 15 0 0 0 0 15 0 0 0 0 0 0 15 0 % M
% Asn: 0 15 0 15 0 0 0 0 0 15 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 15 15 0 0 % P
% Gln: 0 0 0 58 0 0 15 15 15 43 0 43 0 58 0 % Q
% Arg: 0 0 0 0 0 0 0 0 29 43 43 15 0 0 0 % R
% Ser: 0 0 0 0 58 15 0 58 43 0 15 15 0 0 0 % S
% Thr: 0 0 0 15 0 15 0 0 0 0 0 0 0 0 0 % T
% Val: 15 15 15 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 15 0 0 0 0 0 0 15 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 15 0 58 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _